M.Tal Bio

Michal Tal, PhD

Michal Tal, PhD

Michal Caspi Tal (Mikki), is an immunoengineer, and a principal scientist at the Massachusetts Institute of Technology (MIT). Dr. Tal leads the Tal Research Group within the department of Biological Engineering and also serves as the associate scientific director of the Center for Gynepathology Research at MIT. From tick-borne disease to COVID, there are many similarities across the infection-associated chronic illnesses and important sex differences in the immune response to infection which could impact risk for developing chronic illness. Michal is trying to understand why not everyone can just “bounce back” from an infectious disease. She’s combining preclinical and clinical investigation to map distinct illness trajectories and to examine how sex, hormones, and age differences impact these trajectories and disease outcomes. Dr. Tal is running the largest clinical study at MIT, MAESTRO, comparing and contrasting the responses in people suffering from chronic Lyme and Long COVID with comprehensive deeply multi-modal assessments aimed at transforming assessments that are currently subjective into objective informative diagnostics that can point to targeted therapeutics. These involve developing informative metrics for measuring “brain fog”, inflammation, blood flow, barrier integrity, metabolic function, and other key disease determinants. This is complimented to mechanistic research in the mouse model of Lyme disease. Our goal is to replace subjective uncertainty with objective data, empowering patients with a deeper understanding of their own biology and providing scientists and clinicians with a blueprint for deconstructing complex illnesses, identifying mechanism-based endotypes, and accelerating the discovery of targeted, next-generation therapeutics. https://talresearchgroup.mit.edu/

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